CU Boulder engineers have developed a 3D printing technique that allows for localized control of an object鈥檚 firmness, opening up new biomedical avenues that could one day include artificial arteries and organ tissue.
The study, which was , outlines a layer-by-layer printing method that features fine-grain, programmable control over rigidity, allowing researchers to mimic the complex geometry of blood vessels that are highly structured and yet must remain pliable.
The findings could one day lead to better, more personalized treatments for those suffering from hypertension and other vascular diseases.
鈥淭he idea was to add independent mechanical properties to 3D structures that can mimic the body鈥檚 natural tissue,鈥� said Xiaobo Yin, an听associate听professor in CU Boulder鈥檚听Department of Mechanical Engineering听and the senior author of the study. 鈥淭his technology allows us to create microstructures that can be customized for disease models.鈥�
Hardened blood vessels are associated with cardiovascular disease, but engineering a solution for viable artery and tissue replacement has historically proven challenging.听To overcome these hurdles, the researchers found a unique way to take advantage of oxygen鈥檚 role in setting the final form of a 3D-printed structure.
鈥淥xygen is usually a bad thing in that it causes incomplete curing,鈥� said Yonghui Ding, a postdoctoral researcher in Mechanical Engineering and the lead author of the study. 鈥淗ere, we utilize a layer that allows a fixed rate of oxygen permeation.鈥�
By keeping tight control over oxygen migration and its subsequent light exposure, Ding said, the researchers have the freedom to control which areas of an object听are听solidified to be harder or softer鈥攁ll while keeping the overall geometry the same.
鈥淭his is a profound development and an encouraging first step toward our goal of creating structures that function like a healthy cell should function,鈥� Ding said.
As a demonstration, the researchers printed three versions of a simple structure: a top beam supported by two rods. The structures were identical in shape, size and materials, but had been printed with three variations in rod rigidity: soft/soft, hard/soft and hard/hard. The harder rods supported the top beam while the softer rods allowed it to fully or partially collapse.
The researchers repeated the feat with a small Chinese warrior figure, printing it so that the outer layers remained hard while the interior remained soft, leaving the warrior with a tough exterior and a tender heart, so to speak.
The tabletop-sized printer is currently capable of working with biomaterials down to a size of 10 microns, or about one-tenth the width of a human hair. The researchers are optimistic that future studies will help improve the capabilities even further.
鈥淭he challenge is to create an even finer scale for the chemical reactions,鈥� said Yin. 鈥淏ut we see tremendous opportunity ahead for this technology and the potential for artificial tissue fabrication.鈥�
Additional co-authors of the new study include Hang Yin, Yao Zhai and Associate Professor Wei Tan of Mechanical Engineering. The National Science Foundation and the National Institutes of Health provided funding for the research.
